title={Retention of uninfected red blood cells causing congestive splenomegaly is the major mechanism of anemia in malaria},
ISSN={1096-8652},
url={https://doi.org/10.1002/ajh.27152},
DOI={10.1002/ajh.27152},
journal={American Journal of Hematology},
publisher={Wiley},
author={Kho, Steven and Siregar, Nurjati C. and Qotrunnada, Labibah and Fricot, Aurélie and Sissoko, Abdoulaye and Shanti, Putu A. I. and Candrawati, Freis and Kambuaya, Noy N. and Rini, Hasrini and Andries, Benediktus and Hardy, David and Margyaningsih, Nur I. and Fadllan, Fauziyah and Rahmayenti, Desandra A. and Puspitasari, Agatha M. and Leonardo, Leo and Yayang, Bagus T. G. and Margayani, Dewi S. and Prayoga, Pak and Trianty, Leily and Kenangalem, Enny and Price, Ric N. and Yeo, Tsin W. and Minigo, Gabriela and Noviyanti, Rintis and Poespoprodjo, Jeanne R. and Anstey, Nicholas M. and Buffet, Pierre A.},
@@ -187,6 +187,13 @@ Here are the results obtained by adjusting other parameters:
Note that the median total RBC count in asymptomatic participants in the HHS differs very little between uninfected (\(1.75 \times 10^{13}\)) and infected (\(1.73 \times 10^{13}\) for Pf, \(1.66 \times 10^{13}\) for Pv).
Steven Kho:
> We reported in the AJH paper [@Kho23] that asymptomatic infection resulted in a 8.1% loss of circulating RBCs, which translates to 91.9% of steady-state.
> Perhaps the rate of removal of RBCs (except young and old) in the spleen could be tweaked to a smaller fold-change to address this?
If we scale \(\delta_u^{\mathrm{min}}\) by \(0.15\), the steady-state normoblast population is \(8.64 \times 10^{11}\), and the final circulating RBC count is \(\approx 8.3\%\) for Pf and \(\approx 9.7\%\) for Pv.
